Evidence map›Paper›PMID 42239720›Full record

ArticleiScience2026

RepurNet: A network medicine framework for systematic drug repurposing and disease vulnerability discovery.

Sairahul R Pentaparthi, Raymond Zou, Prabal Chhibbar, Aditya Shrawat, Matheus B Belchior, Weiyi Peng, Werner J Geldenhuys, Muhammad Shahzeb Khan, Jason H Huang, Juan I Fuxman Bass and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sairahul R PentaparthiDell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Raymond ZouDepartment of Microbiology and Immunology, Columbia University, New York, NY 10032, USA.
Prabal ChhibbarCenter for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Aditya ShrawatDell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Matheus B BelchiorDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA.
Weiyi PengDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
Werner J GeldenhuysDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA.
Muhammad Shahzeb KhanBaylor Research Institute, and Department of Medicine, Baylor College of Medicine, Temple, TX 76508, USA.
Jason H HuangDepartment of Neurosurgery, Baylor Research Institute and Baylor College of Medicine, Temple, TX 76508, USA.
Juan I Fuxman BassDepartment of Biology, Boston University, Boston, MA 02215, USA.
Jishnu DasCenter for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Nidhi SahniDepartment of Neurosurgery, Baylor Research Institute and Baylor College of Medicine, Temple, TX 76508, USA.
Erxi WuDell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
S Stephen YiDell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug repurposing has become a versatile strategy in rapidly identifying drug candidates to treat disease. Using the early COVID-19 pandemic as an example, we perform a systems-scale

Indexed as

Biological sciencesComputer scienceMedicine

Identifiers

PMID42239720
PMCPMC13226836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.