Evidence map›Paper›PMID 42239620›Full record

ArticleNew journal of chemistry = Nouveau journal de chimie2026

Photocontrolled immunotherapy: a BODIPY-caged MSA-2 for spatiotemporal activation of STING with visible light.

Karan Arora, Alexandra E Lee, Neil C Chada, Jacob A Schulman, John T Wilson

Abstract read
In one paragraph

Article in New journal of chemistry = Nouveau journal de chimie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karan AroraDepartment of Chemical and Biomolecular Engineering, Vanderbilt University Nashville Tennessee 37212 USA john.t.wilson@vanderbilt.edu karan.arora@vanderbilt.edu +1-615-322-6406.ORCID https://orcid.org/0000-0003-1472-1637
Alexandra E LeeDepartment of Biomedical Engineering, Vanderbilt University Nashville Tennessee 37240 USA.
Neil C ChadaDepartment of Biomedical Engineering, Vanderbilt University Nashville Tennessee 37240 USA.ORCID https://orcid.org/0000-0003-4566-3564
Jacob A SchulmanDepartment of Biomedical Engineering, Vanderbilt University Nashville Tennessee 37240 USA.
John T WilsonDepartment of Chemical and Biomolecular Engineering, Vanderbilt University Nashville Tennessee 37212 USA john.t.wilson@vanderbilt.edu karan.arora@vanderbilt.edu +1-615-322-6406.ORCID https://orcid.org/0000-0002-9144-2634

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Expanding the Therapeutic Window of Nanoparticle STING Agonists for Cancer ImmunotherapyR01CA245134 · NCI · VANDERBILT UNIVERSITY · PI WILSON, JOHN TANNER · 2020 to 2025
$1.8M
NCI NIH HHS R01 CA245134NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

The STING pathway is a promising target for cancer immunotherapy, but systemic activation by small-molecule agonists can cause adverse effects. We report a visible light-activatable STING agonist, BODIPY-MSA-2, enabling precise, light-dependent uncaging and restoration of STING activity

Identifiers

PMID42239620
PMCPMC13227911

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.