Evidence map›Paper›PMID 42239603›Full record

ArticleDevice2026

Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels.

Antonio J PereiraTavares, Liam Aranda-Michel, Scott Hahn, Owen Kaufman, Brian D Coffin, Syed Faaz Ashraf, Jason M Szafron, Adam C Straub, Daniel J Shiwarski

Abstract read
In one paragraph

Article in Device, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Antonio J PereiraTavaresDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA.
Liam Aranda-MichelVascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
Scott HahnVascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
Owen KaufmanVascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
Brian D CoffinVascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
Syed Faaz AshrafDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA.
Jason M SzafronDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213, USA.
Adam C StraubVascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
Daniel J ShiwarskiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA.

Funding

Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and DiseaseR35HL161177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adam Carl Straub · 2022 to 2026
$4.7M
Multidisciplinary Research Training in HematologyT32HL149648 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NOVELLI, ENRICO M · 2020 to 2024
$982k
Development of a Collagen-based 3D Bioprinted Microfluidic Platform for Vascular Tissue Engineering and Disease ModelingR00HL155777 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIWARSKI, DANIEL J · 2023 to 2025
$747k
NHLBI NIH HHS R00 HL155777NHLBI NIH HHS R35 HL161177NHLBI NIH HHS T32 HL149648
6 · The paper itself

Abstract

Pressure myography, which is the standard for assessing vascular mechanics and vasoreactivity, is expensive, has low throughput, and is limited to static fluid flow. Here, we developed HemoLens, an open-source 3D-printed pressure myography system for < $750. HemoLens features compact micromanipulators, incremental in-line pressure control, physiological temperature regulation, and modular pulse pressure control between normotensive and hypertensive levels. HemoLen's efficacy was demonstrated by delineation of physiological reactivity and pathological mechanical phenotypes using native mouse arteries and bioprinted acellular scaffolds. Engineered hypertensive vessels demonstrate increased burst pressure (464 mmHg) and reduced dynamic compliance reminiscent of diseased arteries. Together, HemoLens lowers the barrier to entry in pressure myography research by serving as a comprehensive low-cost system for native and engineered vessel characterization.

Indexed as

bioprintinghypertensionmyographyOpen-source

Identifiers

PMID42239603
PMCPMC13229409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.