Evidence map›Paper›PMID 42239563›Full record

ReviewSaudi medical journal2026

Emerging Nanotherapy Applications in Cancer Treatment:

Waleed H Mahallawi

Abstract readReview
In one paragraph

Review in Saudi medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Waleed H MahallawiClinical Laboratory Sciences Department, College of Applied Sciences, Taibah University, Al Madina Al Munawara, Kingdom of Saudi Arabia.ORCID 0000-0001-6977-9006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This comprehensive review synthesizes recent advances in cancer nanotherapy, focusing on 6 emerging categories: immunomodulation, gene/RNA delivery, theranostics, radiosensitization, biomimetic carriers, and artificial intelligence (AI)-guided formulations. These innovative platforms demonstrate transformative potential by overcoming key limitations of conventional cancer treatments. Immunomodulatory nanoparticles reprogram tumor microenvironments and convert immunologically "cold" tumors to "hot" responsive states. Gene delivery systems enable precise editing with >50% efficiency, while theranostic platforms integrate real-time imaging with targeted therapy. Radiosensitizers amplify local radiation dose by twofold, and biomimetic carriers achieve prolonged circulation through immune evasion. An AI-driven approaches optimize personalized formulations based on patient-specific biomarkers. Clinical evidence shows promising safety profiles with predominantly mild-to-moderate adverse events across multiple Phase I-III trials. While nanotherapy represents a paradigm shift in precision oncology, addressing manufacturing reproducibility, long-term safety, and regulatory harmonization remains essential for full clinical translation.

Indexed as

NanomedicineNanoparticlesNeoplasmsGene Transfer TechniquesHumansRadiation-Sensitizing AgentsTheranostic NanomedicineRadiation-Sensitizing AgentsCancerComprehensive reviewNanoparticlesNanotherapy

Identifiers

PMID42239563
PMCPMC13227438

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.