Evidence map›Paper›PMID 42239553›Full record

ReviewSaudi medical journal2026

Integrative Approaches to Gut Microbiota: Biomarkers, Dysbiosis, and Therapeutic Potential.

Zeyad M Alharbi

Abstract readReview
In one paragraph

Review in Saudi medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Zeyad M AlharbiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.ORCID 0009-0005-8231-084X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut contains bacteria, viruses, and archaea that influence health depending on age, diet, and location. An individual harbours about 150 bacterial species. An imbalance of these microorganisms, known as dysbiosis, can negatively impact health. Commensal bacteria maintain microbial homeostasis by building short chain fatty acids. The 2-way communication channel that connects the gut and the brain is referred to as the gut-brain axis. Dysbiosis of the gut leads to some autoimmune diseases. A decline of beneficial bacteria causes the progression of rheumatoid arthritis. Gut dysbiosis increases intestinal permeability, allowing toxins and cytokines to enter the bloodstream and damage neurons. Through interactions with the immune system, the gut microbiota plays a complex role in both health and disease, including contributing to the development of type 1 diabetes. This review stresses the need to integrate measures to identify microbial biomarkers and also metabolic and genetic interplay between the microbiome and health.

Indexed as

DysbiosisGastrointestinal MicrobiomeAutoimmune DiseasesBiomarkersBrain-Gut AxisHumansImmune SystemBiomarkersAutoimmune diseasesBiomarkersDysbiosisGut-brain axisGut microbiotaMulti-omics

Identifiers

PMID42239553
PMCPMC13227343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.