Evidence map›Paper›PMID 42239536›Full record

ReviewFrontiers in cellular and infection microbiology2026

A one health perspective on the intestinal microbiome's role in COVID-19 outcomes and recovery.

Pallavi Singh, Anitha Saravanan, Jeanine Seitz, Nour Alkarzon, Nubwa Medugu

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pallavi SinghDepartment of Biological Sciences, Northern Illinois University, DeKalb, IL, United States.
Anitha SaravananSchool of Nursing, Northern Illinois University, DeKalb, IL, United States.
Jeanine SeitzDepartment of Biological Sciences, Northern Illinois University, DeKalb, IL, United States.
Nour AlkarzonSchool of Nursing, Northern Illinois University, DeKalb, IL, United States.
Nubwa MeduguDepartment of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging infectious diseases, particularly zoonotic ones, remain major global health concerns. The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), highlights the interconnectedness of human, animal, and environmental health within the One Health framework. The intestinal microbiome plays a central role in host immunity and systemic homeostasis, and its disruption has been linked to altered disease severity and recovery patterns in COVID-19. Evidence suggests that SARS-CoV-2 infection induces intestinal dysbiosis, modifies immune signaling, and affects the microbiota-gut-brain axis (MGBA), contributing to neuropsychiatric and metabolic complications. This review synthesizes current findings on the intestinal microbiome's role in COVID-19 pathophysiology and recovery, explores emerging therapeutic strategies including probiotics, prebiotics, and fecal microbiota transplantation, and emphasizes the importance of integrating microbiome research into pandemic preparedness through a One Health approach.

Indexed as

COVID-19Gastrointestinal MicrobiomeAnimalsDysbiosisFecal Microbiota TransplantationHumansPandemicsPrebioticsProbioticsSARS-CoV-2Prebioticsgut dysbiosisintestinal microbiomemicrobiota-gut-brain axis (MGBA)One Health frameworkSARS-CoV-2/COVID-19

Identifiers

PMID42239536
PMCPMC13226561

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.