ArticleFrontiers in pharmacology2026
Integration of an iterative factor into a validated HPTLC method for quantification of koumine in the toxic plant
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: In this research, the iterative factor was integrated into a validated high-performance thin-layer chromatography (HPTLC) method to enhance the precision and reliability of koumine quantification. To establish the validity of the HPTLC assay, precision, repeatability, operating range, robustness, specificity, and recovery analysis were carried out, all of which produced satisfactory results. The amount of koumine for different parts of the Results: The results obtained from both methods were compared, and the percentage of difference ranged from 0.12% to 3.53%, indicating that there were no significance differences. All samples showed that koumine levels were highest in roots regardless of their origin, but the level of koumine in stems and leaves varied geographically. Samples from Fujian Province showed higher indole alkaloid content in the stem, while the leaf samples from Guangxi Province had higher koumine content. Conclusion: These findings indicate that the iterative calibration method is suitable for the quantitative analysis of koumine in
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