Evidence map›Paper›PMID 42239511›Full record

ArticleFrontiers in pharmacology2026

Unveiling the neuroprotective effects of pomegranate extract and/or physical activity against aluminum chloride-induced Alzheimer's disease in rats: modulation of multitude pathways.

Ahmed M E Hamdan, Hadil Alahdal, Haider F S Al-Zubaidy, Karema Abu-Elfotuh, Enji Reda, Yasmen F Mahran, Asmahan Alghamdi, Heba Abdelnaser Aboelsoud, Samia A Ismael, Ehsan K Mohamed and 7 more

Abstract read
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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ahmed M E HamdanDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Hadil AlahdalDepartment of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Haider F S Al-ZubaidyDepartment of Clinical Laboratory Sciences, Faculty of Pharmacy, University of Kufa, Najaf, Iraq.
Karema Abu-ElfotuhClinical Pharmacy Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Enji RedaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University - Kantara Branch, Ismailia, Egypt.
Yasmen F MahranDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Asmahan AlghamdiDepartment of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Heba Abdelnaser AboelsoudDepartment of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Samia A IsmaelDepartment of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ehsan K MohamedBiochemistry Department Egyptian Drug Authority (EDA), Formerly National Organization of Drug Control and Research (NODCAR), Giza, Egypt.
Asmaa A AmerDepartment of Pharmacognosy, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt.
Jilan A NazeamPharmacognosy Department, Faculty of Pharmacy, October 6 University, Giza, Egypt.
Alaadin E El-HaddadPharmacognosy Department, Faculty of Pharmacy, October 6 University, Giza, Egypt.
Khaled R AbdelhakimHistology Department, Misr University for Science and Technology, Cairo, Egypt.
Magy R KozmanClinical Pharmacy Department, Faculty of Pharmacy, Misr University for Science and Technology, Giza, Egypt.
Noura M MohamedDepartment of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Ayah M H GowifelPharmacology and Toxicology Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alzheimer's disease (AD) is a devastating neurodegenerative malady marked by cognitive dysfunction and increased deposition of amyloid-beta and hyperphosphorylated tau proteins. Aluminum-associated neurotoxicity is well-documented and manifests itself in the form of cognitive dysfunction. Nutraceuticals, such as pomegranate extract (POM) or physical activity (PHA), have been recognized to exert beneficial actions on human wellbeing. This study aimed to mechanistically scrutinize the effects of POM and PHA either separately or in combination on AlCl Methods: Sixty adult male Wistar rats were randomly assigned into five groups: control, AlCl Results: PHA and POM, either alone or in combination, exhibited a significant boost in memory and cognitive abilities, evidenced by the significant improvements in behavioral outcomes, elevations in monoamine (DA, NE, 5-HT), LRP1, and neprilysin levels, and reductions in acetylcholinesterase (ACHE) activity, APOE4 levels, and AD markers, relative to the AlCl Conclusion: This study revealed the superiority of the combined therapy, compared to solo treatments, in alleviation of AlCl

Indexed as

Alzheimer’s diseaseamyloidogenesisautophagyendoplasmic reticulum stressP38 mitogen-activated protein kinase/c-jun N-terminal kinase/nuclear factor-kappa B/janus kinase 2/signal transducer and activator of transcription 3physical activitypomegranate extract

Identifiers

PMID42239511
PMCPMC13226161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.