Evidence map›Paper›PMID 42239495›Full record

ArticleMolecular therapy. Nucleic acids2026

Engineered transformer base editor with unconstrained PAM requirements.

Bowen Chen, Yafei Tian, Letong Liang, Pingping Ding, Rui Yin, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Engineered Transformer Base Editor with Enhanced Editing Efficiency.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bowen ChenState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Yafei TianState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Letong LiangState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Pingping DingState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Rui YinState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Rui XuState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Tianyi WangState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Hongyan ChenState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.
Daru LuState Key Laboratory of Genetics and Development of Complex Phenotypes and MOE Engineering Research Center of Gene Technology, School of Life Sciences and Taizhou Institute of Health Science, Fudan University, Shanghai 200438, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canonical base editors (BEs) enable programmable nucleotide conversions without inducing DNA double-strand breaks (DSBs), yet the significant off-target (OT) effects restrict their applications. The transformer BE (tBE), a BE derivative, minimizes DNA and RNA OT mutations, but its dual single-guide RNA (sgRNAs) requirement limits its targeting scope. To address this, we integrated SpRY, a protospacer-adjacent motif (PAM)-relaxed

Indexed as

AAValbinismbase editormiceMT: RNA/DNA editingoff-targetRPESpRYtBE

Identifiers

PMID42239495
PMCPMC13226822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.