Evidence map›Paper›PMID 42239473›Full record

ArticlebioRxiv : the preprint server for biology2026

B3GNT7 regulates mucin glycosylation and protects against colitis and infection.

Mary W N Burns, Joann Chongsaritsinsuk, Daniel C Propheter, Jianyi Yin, Vivian Zuo, Chin Huang, Lan Peng, Kelly A Ruhn, Kelley W Moremen, Ezra Burstein and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mary W N BurnsDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-0712-237X
Joann ChongsaritsinsukDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID 0000-0003-0562-2987
Daniel C PropheterDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8665-0885
Jianyi YinDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1305-5399
Vivian ZuoDepartment of Chemistry, Yale University, New Haven, CT, USA.
Chin HuangComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.ORCID 0000-0002-4296-0400
Lan PengDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kelly A RuhnDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9440-8546
Kelley W MoremenComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.ORCID 0000-0003-1768-582X
Ezra BursteinDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4341-6367
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2759-4641
Stacy A MalakerDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID 0000-0003-2382-5067
Jennifer J KohlerDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5373-3329

Funding

Microbial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9M
Function and regulation of epithelial glycosylationR35GM145599 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Jennifer J Kohler · 2022 to 2026
$2.6M
Chemistry-Biology Interface T32T32GM127216 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI KOHLER, JENNIFER J, PHILLIPS, MARGARET A. · 2019 to 2023
$754k
The Impact of B3GNT7 on Properties of Intestinal Mucus and the Gut MicrobiomeF30DK136209 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURNS, MARY WILTON NEWTON · 2023 to 2024
$79k
NIDDK NIH HHS F30 DK136209NIDDK NIH HHS R01 DK070855NIGMS NIH HHS R35 GM145599NIGMS NIH HHS T32 GM127216
6 · The paper itself

Abstract

Mucus covers and protects colonic epithelial cells. Mucus is mainly composed of heavily O-glycosylated proteins called mucins, and disruption of normal mucin glycosylation occurs in ulcerative colitis (UC). Mucin-2 (MUC2) is the major colonic mucin, and MUC2 O-glycans are often extended with sulfated polyLacNAc, also known as keratan sulfate (KS). The GlcNAc residues in KS are added by B3GNT family members.

Identifiers

PMID42239473
PMCPMC13228267

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.