Evidence map›Paper›PMID 42239469›Full record

ArticlebioRxiv : the preprint server for biology2026

Febuxostat enhances the anti-tumor efficacy of 2-fluoroadenine and 5'-methylthioadenosine in MTAP-deleted cancer.

Baiqing Tang, Hyung-Ok Lee, Daniel Krzikike, Kathy Q Cai, Sapna Gupta, Warren D Kruger

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Baiqing TangCancer Signaling and Microenvironment Program.
Hyung-Ok LeeCancer Signaling and Microenvironment Program.
Daniel KrzikikeCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111.
Kathy Q CaiCancer Signaling and Microenvironment Program.
Sapna GuptaCancer Signaling and Microenvironment Program.
Warren D KrugerCancer Signaling and Microenvironment Program.

Funding

MTAP, 5'-deoxy-5'-methylthioadenosine, and the dysregulation of symmetric dimethylarginine in cancerR01CA245871 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI KRUGER, WARREN D · 2020 to 2024
$2.1M
NCI NIH HHS R01 CA245871
6 · The paper itself

Abstract

Background: Homozygous deletion of the methylthioadenosine phosphorylase ( Materials and Methods: Various combinations of 2FA, MTA, and the xanthine oxidase inhibitor febuxostat (FX) were tested in various cancer cell lines grown Results and conclusions: The treatment of cells with 2FA+MTA

Indexed as

chemotherapymetabolismmethioninemousepurine

Identifiers

PMID42239469
PMCPMC13228241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.