Evidence map›Paper›PMID 42239448›Full record

ArticlebioRxiv : the preprint server for biology2026

Trans-Kingdom dsRNA Sensing:

Alexander W Rapp, Xi Wang, Brandon S Ross, Alayna K Caffrey-Carr, Sean M Thomas, Agustin Resendiz-Sharpe, Andrew J Olive, Katrien Lagrou, Robert A Cramer, Joshua J Obar

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander W RappGeisel School of Medicine at Dartmouth, Department of Microbiology & Immunology, Lebanon, NH 03756, USA.
Xi WangGeisel School of Medicine at Dartmouth, Department of Microbiology & Immunology, Lebanon, NH 03756, USA.
Brandon S RossGeisel School of Medicine at Dartmouth, Department of Microbiology & Immunology, Lebanon, NH 03756, USA.
Alayna K Caffrey-CarrGeisel School of Medicine at Dartmouth, Department of Microbiology & Immunology, Lebanon, NH 03756, USA.
Sean M ThomasDepartment of Microbiology & Molecular Genetics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA.
Agustin Resendiz-SharpeDepartment of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Andrew J OliveDepartment of Microbiology & Molecular Genetics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA.
Katrien LagrouDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Robert A CramerGeisel School of Medicine at Dartmouth, Department of Microbiology & Immunology, Lebanon, NH 03756, USA.
Joshua J ObarGeisel School of Medicine at Dartmouth, Department of Microbiology & Immunology, Lebanon, NH 03756, USA.ORCID 0000-0003-4068-7911

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 2018 to 2026
$13.9M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Evolution of Aspergillus fumigatus virulenceR01AI130128 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2017 to 2026
$4.5M
Fungal spore sensing by MDA5 is necessary for antifungal immunity against Aspergillus fumigatusR01AI139133 · NIAID · DARTMOUTH COLLEGE · PI JOSHUA J OBAR · 2019 to 2026
$3.6M
Genetic Mechanisms of Tissue-Resident Macrophage Maintenance and Function (Supplement)R35GM146795 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2022 to 2026
$2.0M
Dartmouth Cystic Fibrosis Training ProgramT32HL134598 · NHLBI · DARTMOUTH COLLEGE · PI George A. O'Toole · 2017 to 2026
$1.7M
Fungal Pathogenicity Determinants through the Lens of Immune-Targeted Cancer TherapiesR01AI191067 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer, TOBIAS M HOHL · 2025 to 2026
$1.7M
Aspergillus fumigatus persists within alveolar macrophages to drive chronic aspergillosisR01AI191312 · NIAID · DARTMOUTH COLLEGE · PI JOSHUA J OBAR · 2026 to 2026
$631k
NCI NIH HHS P30 CA023108NHLBI NIH HHS T32 HL134598NIAID NIH HHS R01 AI130128NIAID NIH HHS R01 AI139133NIAID NIH HHS R01 AI191067NIAID NIH HHS R01 AI191312NIAID NIH HHS T32 AI007363NIAID NIH HHS T32 AI007519NIDDK NIH HHS P30 DK117469NIGMS NIH HHS P20 GM113132NIGMS NIH HHS R35 GM146795
6 · The paper itself

Abstract

MDA5 is a cytosolic pattern-recognition receptor (PRR) that binds to double-stranded RNA (dsRNA) and subsequently interacts with the signaling adaptor protein MAVS to initiate the antiviral interferon (IFN) response. Our group previously demonstrated that MDA5 is essential for host resistance against the fungal pathogen,

Indexed as

allergic bronchopulmonary aspergillosisalveolar macrophageMAVSmycovirustype I interferon

Identifiers

PMID42239448
PMCPMC13228273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.