ArticlebioRxiv : the preprint server for biology2026
Genetic Architecture of Perivascular Space Morphology in the Pediatric Brain.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Perivascular spaces (PVS) support brain homeostasis through metabolite delivery and waste clearance, yet the genetic determinants of PVS morphology during childhood remain unknown. Here, we leveraged cross-sectional Adolescent Brain Cognitive Development Study data (N = 6,600; ages 9-10), including genomics and 3T structural MRI. Methods: Linear mixed-effects models examined associations between 45 single nucleotide polymorphisms (SNPs) previously linked to adult PVS structure or function and PVS count and volume fraction (VF) across six macroregions and 28 Desikan-Killiany subregions. Results: Fifteen SNPs demonstrated significant associations with PVS macroregion morphology, predominantly VF; 21 SNPs demonstrated associations with subregion morphology. Variants near Conclusion: These findings suggest genetic associations with PVS morphology are detectable in childhood, while highlighting developmental and regional specificity. Longitudinal studies are now needed to determine whether childhood PVS genetic architecture predicts trajectories of glymphatic maturation and associated cognitive outcomes.
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