Evidence map›Paper›PMID 42239411›Full record

ArticlebioRxiv : the preprint server for biology2026

Piezo3 is a novel mechanosensitive Piezo ion channel in vertebrates.

Ziyu Dong, Dingxun Wang, Beichen Wang, Jillian A New, Yuk Fai Leung, GuangJun Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ziyu DongDepartment of Comparative Pathobiology; Purdue University, 625 Harrison Street, West Lafayette, Indiana. 47906. USA.
Dingxun WangDepartment of Comparative Pathobiology; Purdue University, 625 Harrison Street, West Lafayette, Indiana. 47906. USA.
Beichen WangDepartment of Biological Sciences; Purdue University, 625 Harrison Street, West Lafayette, Indiana. 47906. USA.
Jillian A NewDepartment of Biological Sciences; Purdue University, 625 Harrison Street, West Lafayette, Indiana. 47906. USA.
Yuk Fai LeungDepartment of Biological Sciences; Purdue University, 625 Harrison Street, West Lafayette, Indiana. 47906. USA.
GuangJun ZhangDepartment of Comparative Pathobiology; Purdue University, 625 Harrison Street, West Lafayette, Indiana. 47906. USA.ORCID 0000-0002-0839-5161

Funding

Roles of ion-channel mediated bioelectricity in developmental patterningR35GM124913 · NIGMS · PURDUE UNIVERSITY · PI GuangJun Zhang · 2017 to 2026
$4.2M
NIGMS NIH HHS R35 GM124913
6 · The paper itself

Abstract

Mechanosensing and mechanotransduction are essential for all living cells. In mammals, Piezo1 and Piezo2 are two mechanically activated cation channels that serve as mechanosensors for a variety of physiological and pathological processes, ranging from touch sensing to sickle cell disease. These two channels are well evolutionarily conserved, and orthologous genes can be traced back to the origin of vertebrates, which underwent whole-genome duplications (WGDs). The number of paralogous genes originating from the vertebrate WGD varies across gene families. Thus, whether there are more

Indexed as

mechanosensingohnologPiezo3whole-genome duplication (WGD)zebrafish

Identifiers

PMID42239411
PMCPMC13228305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.