Evidence map›Paper›PMID 42239409›Full record

ArticlebioRxiv : the preprint server for biology2026

CMPK2 restricts

John Neff, Victoria A Ektnitphong, Priscila C Campos, Kubra F Naqvi, Beatriz R S Dias, Kathryn C Rahlwes, Zhenyu Zhong, Michael U Shiloh

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John NeffDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
Victoria A EktnitphongDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.ORCID 0009-0007-1276-6563
Priscila C CamposDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.ORCID 0000-0003-1789-3290
Kubra F NaqviDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.ORCID 0000-0003-4703-9466
Beatriz R S DiasDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.ORCID 0000-0001-7433-3869
Kathryn C RahlwesDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.ORCID 0000-0002-8101-5604
Zhenyu ZhongDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, USA.
Michael U ShilohDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.ORCID 0000-0003-4329-2253

Funding

RP5: Chemical proteomic discovery of small-molecule probes for autophagy proteinsU19AI142784 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VIRGIN, HERBERT W · 2019 to 2023
$36.9M
MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Deciphering the Role of dNTP Metabolism in Innate ImmunityR35GM142654 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ZHONG, ZHENYU · 2021 to 2025
$2.2M
NIAID NIH HHS T32 AI007520NIAID NIH HHS U19 AI142784NIGMS NIH HHS R35 GM142654
6 · The paper itself

Abstract

Host cell metabolic pathways influence innate immune responses to intracellular pathogens, but the contribution of nucleotide metabolism to antimicrobial defense remains incompletely defined. Here, we identify the mitochondrial nucleoside monophosphate kinase CMPK2 as a regulator of macrophage responses to

Identifiers

PMID42239409
PMCPMC13228414

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.