Evidence map›Paper›PMID 42239394›Full record

ArticlebioRxiv : the preprint server for biology2026

Inflammatory Stromal Aging in Ulcerative Colitis and Colitis-Associated Cancer.

Khalil Almotah, Uyen Tran, Haylee Gilbert, R Allen Schweickart, Robert C Fisher, Yaroslav Bisikalo, Manal Ali, Munir Buhaya, Mingyuan Cheng, Michael Cruise and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Khalil AlmotahDept. Cardiovascular & Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.ORCID 0009-0009-2456-5528
Uyen TranDept. Cardiovascular & Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.ORCID 0000-0002-6498-9765
Haylee GilbertDept. Cardiovascular & Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.
R Allen SchweickartDept. Cardiovascular & Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.ORCID 0000-0001-9126-7883
Robert C FisherDept. Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.
Yaroslav BisikaloDept. of Surgery, UT Southwestern Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390.
Manal AliDept. of Surgery, UT Southwestern Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390.
Munir BuhayaDept. of Surgery, UT Southwestern Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390.
Mingyuan ChengDept. of Surgery, UT Southwestern Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390.
Michael CruiseDept. of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.
Zhikai ChiSimmons Comprehensive Cancer Center, University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390.
Samaneh Kamali SarvestaniDept. Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.
Emina H HuangDept. Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.ORCID 0000-0003-2495-4370
Oliver WesselyDept. Cardiovascular & Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.ORCID 0000-0001-6440-7975

Funding

An organotypic model recapitulating colon cancer microenvironment and metastasisU01CA214300 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, EMINA HUI-NA, SHEN, XILING · 2017 to 2021
$3.1M
The miR-20/c-Myc/E2F Regulatory Axis is Critical for the Tumor Promoting Activity of Inflammatory Fibroblasts in Colitis-Associated CancerR01CA237304 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, EMINA HUI-NA, WESSELY, OLIVER · 2019 to 2023
$2.9M
NCI NIH HHS R01 CA237304NCI NIH HHS U01 CA214300
6 · The paper itself

Abstract

Ulcerative colitis is a chronic inflammatory bowel disease that can progress from dysplasia to cancer. Inflammatory responses are critical drivers in this process, typically triggered by epithelial lesions and the ensuing infiltration of microbiota into the interstitial layer. Here, we focus on the pro-inflammatory state of the interstitial fibroblasts, which promotes immune infiltration and augments disease progression. The study aims to provide a mechanistic link how fibroblasts of the colitis-associated microenvironment integrate inflammatory signals, microbial infiltration and cellular memory. To this end, we investigated a large number of primary colon fibroblasts obtained from normal, colitis and colon cancer samples using a range of

Indexed as

Colitis-associated cancerCXCL8fibroblastsiPSC reprogrammingNF-κB signalingSenescence-associated secretory phenotype (SASP)ulcerative colitis

Identifiers

PMID42239394
PMCPMC13228400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.