Evidence map›Paper›PMID 42239362›Full record

ArticlebioRxiv : the preprint server for biology2026

Microplastics inhibit macrophage bioenergetics impairing homeostatic function and immune responsiveness.

Rajeev Dhupar, Hannah M Udoh, Naila Noureen, Charles E Bardawil, Xinyue Zhao, Mohsin Cheema, Shivani Tuli, Dylan Shields, Ksenia Mats, Omar Al-Bataineh and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rajeev DhuparDepartment of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-9581-3340
Hannah M UdohDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0009-0000-1561-920X
Naila NoureenDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Charles E BardawilDepartment of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0009-0004-6121-9097
Xinyue ZhaoChemical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Mohsin CheemaDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0009-0002-5590-0199
Shivani TuliDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0009-0004-2045-2466
Dylan ShieldsDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Ksenia MatsDepartment of Biology and Data Science, Bryn Mawr College, Bryn Mawr, PA, USA.
Omar Al-BatainehDepartment of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Laila GollaDepartment of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Angel WangChemical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Ricardo H PinedaDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Melanie KoenigshoffDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Shikhar UttamDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0897-2918
David M GauDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-3079-3692
Adam C SoloffSurgical Services and Research Division, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.ORCID 0000-0002-1467-8168

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
BLRD VA I01 BX006358CSRD VA I01 CX002558NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

Since the 1950s, micro- and nanoplastics (MNPs) have become omnipresent, representing a novel environmental hazard which continually deposits in our airways. Pulmonary macrophages (pMacs) orchestrate the balance between inflammation and tolerance required for homeostasis of the lung and are among the first immune cells to encounter inhaled MNPs. Yet, how pMacs react to plastic deposition in the lung and implications for disease remain unknown. Here, we exposed mice

Indexed as

antigen presentationMacrophagemicroplasticsmitochondria

Identifiers

PMID42239362
PMCPMC13228642

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.