ArticlebioRxiv : the preprint server for biology2026
Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlu
Justin B Steinfeld, Xia Lei, Madeline Laramee, Xin Lin, Alice L Rodriguez, Paul K Spearing, Wesley B Asher, Colleen M Niswender, Jonathan A Javitch
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Justin B SteinfeldDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0003-0325-7058 Xia LeiDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Madeline LarameeDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Xin LinDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Alice L RodriguezDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Paul K SpearingDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Wesley B AsherDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0001-7437-218X Colleen M NiswenderDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Jonathan A JavitchDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0001-7395-2967 Funding
Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0MREGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9MFUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPESR01NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 1993 to 2025
$6.2MPRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRYR25MH086466 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Melissa Arbuckle, Eduardo David Leonardo · 2009 to 2026
$4.3MDiscovery of mGlu receptor PAMs for treatment of schizophreniaR01MH119673 · NIMH · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2019 to 2023
$3.6MImpact of Metabotropic Glutamate Receptor Heteromerization on Signaling and PharmacologyR01NS132060 · NINDS · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Jonathan A Javitch, COLLEEN M NISWENDER · 2023 to 2026
$2.4MResearch Education in Child and Adolescent Psychiatry ResidencyR25MH125775 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Kate Dimond Fitzgerald, Jeremy Veenstra-VanderWeele · 2021 to 2026
$1.3MNIMH NIH HHS R01 MH054137NIMH NIH HHS R01 MH062646NIMH NIH HHS R01 MH119673NIMH NIH HHS R25 MH086466NIMH NIH HHS R25 MH125775NINDS NIH HHS R01 NS031373NINDS NIH HHS R01 NS132060
6 · The paper itselfAbstract
Class C GPCRs function as obligate dimers in which only one G protein can engage the complex at a time, but how each protomer contributes to heterodimer coupling has remained unresolved. Using CODA-RET, a BRET-based assay reporting direct Gα
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PMID42239350
PMCPMC13228339
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