Evidence map›Paper›PMID 42239343›Full record

ArticlebioRxiv : the preprint server for biology2026

Combinatorial transcription factor interactions drive modular gene regulatory networks.

Jialei Duan, Boxun Li, Kartik Kulkarni, Gabriela Orquera-Tornakian, Daryl Barth, Lei Wang, Vrushali Pandit, Joel Liou, Nikhil V Munshi, Gary C Hon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jialei DuanLaboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Boxun LiLaboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kartik KulkarniDepartment of Molecular Biology, Department of Internal Medicine, Division of Cardiology, McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Gabriela Orquera-TornakianDepartment of Molecular Biology, Department of Internal Medicine, Division of Cardiology, McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Daryl BarthLaboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lei WangLaboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Vrushali PanditDepartment of Molecular Biology, Department of Internal Medicine, Division of Cardiology, McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Joel LiouLaboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Nikhil V MunshiDepartment of Molecular Biology, Department of Internal Medicine, Division of Cardiology, McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Gary C HonLaboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1615-0391

Funding

Multiscale functional characterization of genomic variation in human developmental disordersUM1HG011996 · NHGRI · UT SOUTHWESTERN MEDICAL CENTER · PI Gary Chung Hon, WILLIAM Lee KRAUS · 2021 to 2026
$10.5M
Combinatorial Biology of Gene Regulation for Cellular EngineeringDP2GM128203 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI HON, GARY CHUNG · 2017 to 2021
$2.9M
Determinants of Cell State ReprogrammingR35GM145235 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Gary Chung Hon · 2022 to 2026
$2.3M
Diversity Supplement- Analysis of transcriptional and chromatin accessibility during atrioventricular node formatR01HL136604 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MUNSHI, NIKHIL VILAS · 2017 to 2021
$2.1M
Exploring Mechanisms of Cardiac Pacemaker Cell Fate DeterminationR01HL151650 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MUNSHI, NIKHIL VILAS · 2021 to 2025
$2.1M
Systematic Assessment of Combinatorial Transcription Factor ActivityR56HG012768 · NHGRI · UT SOUTHWESTERN MEDICAL CENTER · PI HON, GARY CHUNG, MUNSHI, NIKHIL VILAS · 2023 to 2023
$400k
NHGRI NIH HHS R56 HG012768NHGRI NIH HHS UM1 HG011996NHLBI NIH HHS R01 HL136604NHLBI NIH HHS R01 HL151650NIGMS NIH HHS DP2 GM128203NIGMS NIH HHS R35 GM145235
6 · The paper itself

Abstract

Transcription factors (

Indexed as

cellular reprogrammingcombinatorial biologygene regulatory networksingle-cell RNA-Seqsingle-cell screenstranscription factor

Identifiers

PMID42239343
PMCPMC13228708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.