Evidence map›Paper›PMID 42239336›Full record

ArticlebioRxiv : the preprint server for biology2026

tRNA-derived fragments elevated in Alzheimer's disease promote Tau aggregation.

Ami Kobayashi, Chung-Ta Han, Lien D Nguyen, Karen Tsay, Mariana Bms Martins, Prakash Kharel, Yanhong Zhang, M Inmaculada Barrasa, Allison M Williams, Nana Kunii and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ami KobayashiDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.ORCID 0000-0001-7347-7537
Chung-Ta HanDepartment of Chemistry, Northwestern University, Evanston, IL, 60208.
Lien D NguyenDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.
Karen TsayDepartment of Chemistry, Northwestern University, Evanston, IL, 60208.
Mariana Bms MartinsDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129.
Prakash KharelDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, 66160.
Yanhong ZhangDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.
M Inmaculada BarrasaDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.
Allison M WilliamsDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.
Nana KuniiDepartment of Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Yasutoshi AkiyamaDepartment of Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Vikram KhuranaDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129.
Pavel IvanovDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.
Songi HanDepartment of Chemistry, Northwestern University, Evanston, IL, 60208.
Anna M KrichevskyDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
Molecular Basis of the Tau Aggregation PathwayR01AG056058 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han, KENNETH Stephen KOSIK · 2017 to 2026
$6.4M
tRNA fragments and their role in tau pathology in Alzheimer's disease and tauopathiesRF1AG090598 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KRICHEVSKY, ANNA M. · 2025 to 2025
$3.7M
Water as essential building blocks to direct protein structure and functionR35GM136411 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han · 2020 to 2026
$2.4M
Biology of RNA G-quadruplexesR01GM126150 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2019 to 2023
$1.9M
tRNA-derived stress-induced RNAs and translational controlR01GM146997 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2022 to 2025
$1.6M
STRUCTURAL BIOL RES: LUNG SURFACTANT PROTEINS, DISTRESSS10RR019071 · NCRR · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2005 to 2005
$272k
600 MHz NMR Instrument Upgrade at Northwestern UniversityS10OD012016 · OD · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2012 to 2012
$267k
NCI NIH HHS P30 CA060553NCRR NIH HHS S10 RR019071NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG056058NIA NIH HHS RF1 AG090598NIGMS NIH HHS R01 GM126150NIGMS NIH HHS R01 GM146997NIGMS NIH HHS R35 GM136411NIH HHS S10 OD012016
6 · The paper itself

Abstract

Tauopathies, including Alzheimer's disease (AD), are driven by pathological Tau aggregation, a process that requires co-factors. Small RNAs (sRNA) have been proposed as such co-factors, yet little is known about endogenous transcripts that promote Tau pathology. We identify stress-induced tRNA-derived RNAs or fragments (tDRs/tRFs) as the most dysregulated sRNA class in human AD brains, PS19 mice overexpressing mutant human Tau, and human neuronal tauopathy models. Notably, the highly accumulating 5'Glu

Indexed as

Alzheimer’s diseaseextracellular RNATau aggregationTau bindertauopathiesTau propagationtRNA-derived fragments

Identifiers

PMID42239336
PMCPMC13228447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.