Evidence map›Paper›PMID 42239331›Full record

ArticlebioRxiv : the preprint server for biology2026

Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis.

Tingting W Mills, Chorong Han, Ji Ye Lim, Nobuya Koike, Sun Young Kim, Jaebok Wi, Hui Liu, Yu Wang, Kazuhiro Yagita, Joseph L Alcorn and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tingting W MillsDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.
Chorong HanDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.
Ji Ye LimDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.
Nobuya KoikeDepartment of Physiology and Systems Bioscience, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Sun Young KimDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.
Jaebok WiDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.
Hui LiuDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.
Yu WangDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.
Kazuhiro YagitaDepartment of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, Japan.
Joseph L AlcornDepartment of Pediatrics, the University of Texas Health Science Center at Houston, Houston, TX.
Zheng ChenDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0002-2464-5474
Seung-Hee YooDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center at Houston, Houston, TX.

Funding

Circadian regulation of mitochondrial function by muscle RORs to promote healthy agingR01AG089967 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zheng Chen · 2024 to 2026
$2.5M
Mammalian circadian rhythms: from genes to mechanismsR35GM145232 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Seung-Hee Yoo · 2022 to 2026
$2.2M
Macrophage NUDT21-mediated alternative polyadenylation in lung injuryR01HL168128 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Tingting Weng Mills · 2024 to 2026
$1.6M
Regulatory role of APA in pulmonary fibrosis during agingR56AG076144 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHEN, ZHENG, MILLS, TINGTING WENG · 2022 to 2022
$320k
NHLBI NIH HHS R01 HL168128NIA NIH HHS R01 AG089967NIA NIH HHS R56 AG076144NIGMS NIH HHS R35 GM145232
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by alveolar destruction, impaired epithelial regeneration and chronic inflammation. While circadian disruption has been linked to COPD pathogenesis, the cellular mechanisms remain unclear. Here, we identify the core clock components Cryptochrome 1 and 2 (

Indexed as

alveolar epithelial cellCircadian clockCOPDCRY1 and CRY2emphysemaNobiletin

Identifiers

PMID42239331
PMCPMC13228625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.