Evidence map›Paper›PMID 42239324›Full record

ArticlebioRxiv : the preprint server for biology2026

Taxol exploits molecular switches within tubulin to stabilize microtubules.

Nicholas Vangos, Patrick DeLear, Ezekiel C Thomas, Kristen J Verhey, Morgan E DeSantis, Marija Zanic, David Sept, Michael A Cianfrocco

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas VangosCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-3861-9242
Patrick DeLearDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-1013-0138
Ezekiel C ThomasDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-9810-0477
Kristen J VerheyDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-9329-4981
Morgan E DeSantisDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-4096-8548
Marija ZanicDepartment of Cell and Developmental Biology, Department of Chemical and Biomolecular Engineering, Department of Biochemistry, Vanderbilt University, Nashville, TN 37205.ORCID 0000-0002-5127-5819
David SeptDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-3719-2483
Michael A CianfroccoDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-2067-4999

Funding

Kinesin Motors and Microtubule-based TraffickingR35GM131744 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristen J. Verhey · 2019 to 2026
$6.3M
Biophysical Principles of Microtubule DynamicsR35GM119552 · NIGMS · VANDERBILT UNIVERSITY · PI Marija Zanic · 2016 to 2026
$4.4M
Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
Mechanisms of kinesin motor protein inhibition: Equipment SupplementR01GM141119 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Cianfrocco · 2022 to 2026
$1.8M
Mechanisms of dynein regulationR35GM146739 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Morgan DeSantis · 2022 to 2026
$1.7M
Dynamic Regulation of the Actin Filament Barbed EndR01GM136822 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEPT, DAVID · 2020 to 2023
$1.2M
Compute Cluster for in vitro and in situ Analysis of Molecular MachinesS10OD030275 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OHI, MELANIE DIANE · 2021 to 2021
$600k
NIGMS NIH HHS R01 GM136822NIGMS NIH HHS R01 GM141119NIGMS NIH HHS R35 GM119552NIGMS NIH HHS R35 GM131744NIGMS NIH HHS R35 GM146739NIGMS NIH HHS T32 GM145470NIH HHS S10 OD030275
6 · The paper itself

Abstract

Microtubules are dynamic filaments of tubulin heterodimers that comprise an essential part of the eukaryotic cytoskeleton

Identifiers

PMID42239324
PMCPMC13228586

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.