ArticlebioRxiv : the preprint server for biology2026
Temporal cortex astrocytic Gi-GPCR signaling regulates learned threat responses.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
Astrocytes are increasingly recognized as dynamic modulators of brain circuit function, memory processing, and behavior. Emerging evidence suggests that astrocytic G-protein-coupled receptors (GPCRs) are key regulators of these processes through their influence on intracellular signaling and neuron-glia interactions. Here, we show that the repertoire of functionally expressed GPCRs in cortical astrocytes is broader than previously appreciated. Yet, how distinct GPCR pathways contribute to behavioral regulation remains unknown for most brain areas and behavioral contexts. We therefore investigated the role of astrocytic GPCR signaling in the temporal cortex, a region that integrates multimodal sensory information and learned fear associations. Using chemogenetic tools to selectively activate distinct GPCR pathways in astrocytes, we demonstrate that Gi-coupled GPCR signaling, but not Gs- or Gq-coupled signaling, enhances fear memory retrieval.
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Registered trials
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