Evidence map›Paper›PMID 42239271›Full record

ArticlebioRxiv : the preprint server for biology2026

In Vivo 4D Oxy-Wavelet MRI as a Non-Invasive Biomarker of Brain Mitochondrial Function across the Lifespan.

Devin Raine Everaldo Cortes, Sean Hartwick, Thomas Becker-Szurszewski, Kristina Elsa Schwab, Cody Ruck, Shanim Manzoor, Noah William Coulson, Dalton West, Margaret Caroline Stapleton, Samuel Wyman and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Devin Raine Everaldo CortesDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Sean HartwickDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Thomas Becker-SzurszewskiDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kristina Elsa SchwabDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Cody RuckDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Shanim ManzoorDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Noah William CoulsonDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Dalton WestDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Margaret Caroline StapletonDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Samuel WymanDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Cecilia Wen-Ya LoDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Sivakama BharathiDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Eric S GoetzmanDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Anthony G ChristodoulouDepartment of Radiological Sciences, David Geffen School of Medicine, at UCLA, Los Angeles, CA, USA.
Yijen Lin WuDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Gating-Free Ultra-Fast Fetal Cardiac MRI with Sub-Nyquist Sampling for Live in Utero Imaging and Cardiovascular Phenotyping of Fetal MiceR21EB023507 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, YIJEN LIN · 2019 to 2020
$452k
Bioenergetics and Neuronal Network Remodeling in a Rodent Model of Temporal Lobe EpilepsyR21NS121706 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, YIJEN LIN · 2022 to 2023
$439k
Non-invasive Imaging for Therapeutic Efficacy (NITE) in Ndufs4 Mouse Model of Leigh SyndromeR21NS142555 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, YIJEN LIN · 2025 to 2025
$417k
NIBIB NIH HHS R21 EB023507NINDS NIH HHS R21 NS121706NINDS NIH HHS R21 NS142555
6 · The paper itself

Abstract

Mitochondria are essential for cellular energy production and are particularly critical for brain development and function. Neurons rely predominantly on oxidative phosphorylation for energy production, rendering the brain highly vulnerable to mitochondrial dysfunction. Consequently, impaired mitochondrial function contributes to a broad spectrum of neurological and systemic disorders, making mitochondria attractive therapeutic targets. Despite this importance, there is currently no non-invasive, spatially resolved method to assess mitochondrial function in the intact living brain. Here, we establish a non-invasive functional MRI approach-4D Oxy-wavelet MRI-to probe in vivo mitochondrial electron transport chain (ETC) function in a spatially specific manner across the lifespan, from fetal to adult brains. This method employs a low-rank

Indexed as

brainfetalfMRIlow-rank reconstructionMitochondriawavelet analysis

Identifiers

PMID42239271
PMCPMC13228471

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.