Evidence map›Paper›PMID 42239241›Full record

ArticlebioRxiv : the preprint server for biology2026

Historically Small Population Size Limits Purging of Deleterious Mutations in a Conservation-Reliant Species, the Kirtland's Warbler.

Anna María Calderón, Alexander T Salis, David P L Toews, Zachary A Szpiech

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna María CalderónDepartment of Biology, Pennsylvania State University, 619 Mueller Laboratory, University Park, State College, PA 16802, USA.ORCID 0000-0003-1044-1160
Alexander T SalisDivision of Vertebrate Zoology, American Museum of Natural History, New York, New York, USA.ORCID 0000-0002-3205-3006
David P L ToewsDepartment of Biology, Pennsylvania State University, 619 Mueller Laboratory, University Park, State College, PA 16802, USA.ORCID 0000-0002-9763-0476
Zachary A SzpiechDepartment of Biology, Pennsylvania State University, 619 Mueller Laboratory, University Park, State College, PA 16802, USA.ORCID 0000-0001-6372-8224

Funding

Population Genetics Methods for Understanding Complex Trait EvolutionR35GM146926 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Zachary Alfano Szpiech · 2022 to 2026
$1.8M
NIGMS NIH HHS R35 GM146926
6 · The paper itself

Abstract

Strong population contractions can leave a persistent genomic legacy that can influence populations long after their demographic recovery. While bottlenecks facilitate the removal of strongly deleterious mutations, the effectiveness of purging may be limited in historically small populations. The Kirtland's warbler (

Indexed as

conservation genomicsEvolutiongenetic loadhistorical DNAinbreedingruns of homozygositySetophaga kirtlandii

Identifiers

PMID42239241
PMCPMC13228649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.