Evidence map›Paper›PMID 42239234›Full record

ArticlebioRxiv : the preprint server for biology2026

Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making.

Bianca T Leonard, Maria Alejandra Martinez-Ortiz, Jason Bock, Yifan Zhang, Steve Flores, Derek Vincent Taylor, Laura M Glynn, Elysia Poggi Davis, Hal S Stern, Tallie Z Baram and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bianca T LeonardDepartment of Neurobiology and Behavior, University of California, Irvine.
Maria Alejandra Martinez-OrtizDepartment of Psychology, Stanford University.
Jason BockDepartment of Neurobiology and Behavior, University of California, Irvine.
Yifan ZhangDepartment of Cognitive Sciences, University of California, Irvine.
Steve FloresDepartment of Neurobiology and Behavior, University of California, Irvine.
Derek Vincent TaylorDepartment of Neurobiology and Behavior, University of California, Irvine.
Laura M GlynnDepartment of Psychology, Chapman University.ORCID 0000-0001-5903-8685
Elysia Poggi DavisDepartment of Psychology, University of Denver.ORCID 0000-0001-6345-9271
Hal S SternDepartment of Statistics, University of California, Irvine.
Tallie Z BaramDepartment of Anatomy & Neurobiology, University of California, Irvine.
Catherine A HartleyDepartment of Psychology, New York University.ORCID 0000-0003-0177-7295
Michael A YassaDepartment of Neurobiology and Behavior, University of California, Irvine.
Aaron BornsteinCenter for the Neurobiology of Learning and Memory, University of California, Irvine.ORCID 0000-0001-6251-6000

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4M
Testing a Memory-Based Hypothesis for AnhedoniaR01MH128306 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI JULIAN F. THAYER, Michael A Yassa · 2023 to 2026
$3.2M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
NIMH NIH HHS P50 MH096889NIMH NIH HHS R01 MH128306NIMH NIH HHS T32 MH119049
6 · The paper itself

Abstract

Anhedonia - the diminished capacity to experience or anticipate pleasure - is among the most common consequences of early-life unpredictability, yet how these co-occurring conditions jointly shape real-world decision-making remains unknown. Here, we use a sequential foraging-under-threat task to probe motivational conflict decisions in 357 individuals varying in early-life unpredictability and anhedonia symptoms. We find that unpredictability and anhedonia exert

Indexed as

computational psychiatryearly life adversityforagingmotivational conflictstress

Identifiers

PMID42239234
PMCPMC13228362

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.