Evidence map›Paper›PMID 42239216›Full record

ArticlebioRxiv : the preprint server for biology2026

Quantitative CDK2 Dynamics Are Linked to Cell Fate Decisions in Differentiating Trophoblast Stem Cells.

Sage Indigo G Brill, Upasna Sharma, Estefania Sanchez-Vasquez, Ali Shariati

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sage Indigo G BrillDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.
Upasna SharmaDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.
Estefania Sanchez-VasquezDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.
Ali ShariatiDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.

Funding

IRACDA at UCSC and CSUMBK12GM139185 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI FORSBERG, CAMILLA, HINCK, LINDSAY E · 2020 to 2024
$4.1M
Paternal contributions to offspring health: Intergenerational epigenetic inheritance via sperm small RNAsDP2AG066622 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SHARMA, UPASNA · 2019 to 2019
$2.3M
Molecular feedback between cell division cycle and differentiation in pluripotent stem cellsR35GM147395 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Ali Shariati · 2022 to 2026
$1.9M
A postdoctoral training program for impactful careers in stem cell biologyT32HD108079 · NICHD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Bin Chen, CAMILLA FORSBERG · 2022 to 2026
$1.1M
Determining feedback mechanisms between cell cycle and cell fate in pluripotent cellsR00GM126027 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SHARIATI, ALI · 2020 to 2022
$747k
BSLII Stationed Zeiss 880 Confocal Microscope with AiryscanS10OD023528 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2017 to 2017
$456k
NIA NIH HHS DP2 AG066622NICHD NIH HHS T32 HD108079NIGMS NIH HHS K12 GM139185NIGMS NIH HHS R00 GM126027NIGMS NIH HHS R35 GM147395NIH HHS S10 OD023528
6 · The paper itself

Abstract

During early development of the placenta, a subset of murine trophectoderm stem cells (TSCs) undergo endoreplication, an unusual form of cell division cycle that decouples DNA synthesis from cytokinesis, resulting in physiological polyploidy. Oscillations in CDK2 activity are essential for the orderly progression of the cell cycle to ensure replicated DNA is accurately partitioned into two daughter cells. However, it remains underexplored how the dynamics of CDK2 activity regulate endoreplication in the context of TSCs differentiation. To address this question, we leveraged the variability in cell fate decisions in an established

Indexed as

CDK2 dynamicsEndoreplicationLive-cell imagingPlacental developmentTrophectoderm stem cells

Identifiers

PMID42239216
PMCPMC13228524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.