Evidence map›Paper›PMID 42239215›Full record

ArticlebioRxiv : the preprint server for biology2026

Evidence that local viscosity and NOX-dependent ROS increases render the tardigrade H. exemplaris resilient to extreme physical force.

Molly J Kirk, Jonathan Paules, Samantha L Fiallo, Amelia M Leeman, Carl D Meinhart, Joel H Rothman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Molly J KirkDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA.ORCID 0000-0003-2265-6169
Jonathan PaulesDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA.
Samantha L FialloDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA.ORCID 0000-0002-9530-3092
Amelia M LeemanDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA.
Carl D MeinhartDepartment of Mechanical Engineering, University of California, Santa Barbara, Santa Barbara, CA.ORCID 0009-0004-1293-3673
Joel H RothmanDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA.ORCID 0000-0002-6844-1377

Funding

Developmental reprogramming and transorganogenesisR01HD081266 · NICHD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Joel H. Rothman · 2015 to 2026
$3.0M
Neuroresilience to hyper-gravity and desiccation in tardigrade Hypsibius exemplarisF32AG081056 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KIRK, MOLLY J · 2023 to 2025
$221k
NIA NIH HHS F32 AG081056NICHD NIH HHS R01 HD081266
6 · The paper itself

Abstract

Biological phase changes provoked by stress, such as vitrification or gel-sol transitions, enable many organisms, including extremotolerant tardigrades, to enter quiescent states and survive extreme environmental conditions. Protein-driven phase transitions are hypothesized to produce large-scale changes in intracellular viscosity, allowing tardigrades to survive extreme stresses such as desiccation. We report that the tardigrade

Indexed as

HypergravityIntracellular viscosityMajor PhysiologyMinor Cell BiologyStress ResilienceTardigrade

Identifiers

PMID42239215
PMCPMC13228310

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.