Evidence map›Paper›PMID 42239186›Full record

ArticlebioRxiv : the preprint server for biology2026

Divergent RNA structures support accurate splicing of the SF3B1-sensitive

Austin Herbert, Alexandra Randazza, Abigail Hatfield, Lela Lackey

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Austin HerbertDepartment of Genetics and Biochemistry, Institute for Human Genetics Clemson University, Greenwood, SC.ORCID 0000-0002-6283-7784
Alexandra RandazzaDepartment of Genetics and Biochemistry, Institute for Human Genetics Clemson University, Greenwood, SC.ORCID 0009-0002-7869-1748
Abigail HatfieldDepartment of Genetics and Biochemistry, Institute for Human Genetics Clemson University, Greenwood, SC.ORCID 0000-0002-8728-2105
Lela LackeyDepartment of Genetics and Biochemistry, Institute for Human Genetics Clemson University, Greenwood, SC.ORCID 0000-0003-2163-4005

Funding

Statistical Methods for Gene Regulatory Analysis From Single Cell Genomics DataP20GM139769 · NIGMS · CLEMSON UNIVERSITY · PI ANHOLT, ROBERT R. H, ARNO, GAVIN · 2021 to 2025
$10.8M
Pre-mRNA intronic structures in trans factor binding and alternative splicingR35GM142851 · NIGMS · CLEMSON UNIVERSITY · PI LACKEY, LELA LYNN · 2021 to 2025
$1.8M
NIGMS NIH HHS P20 GM139769NIGMS NIH HHS R35 GM142851
6 · The paper itself

Abstract

Splicing is governed by interactions between the spliceosome and precursor RNA sequence and structural elements. However, the relative contributions of RNA sequence and structural elements remain unclear. Here, we systematically dissect these determinants using a high-throughput mutagenesis approach with the

Indexed as

cryptic splicingMAP3K7RNA structureSF3B1SHAPE-MaPsplicing

Identifiers

PMID42239186
PMCPMC13228592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.