Evidence map›Paper›PMID 42239176›Full record

ArticlebioRxiv : the preprint server for biology2026

Allele-specific antisense oligonucleotide treatment rescues

Shlomit Ezer, Shira Yanovsky-Dagan, Amit Granit, Matthew McDougal, Taeyoung Hwang, Israel Antman, Rotem Karni, Wan Hee Yoon, Ann Saada, Adi Inbal and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shlomit EzerDepartment of Genetics, Hadassah Medical Organization, Jerusalem, Israel.
Shira Yanovsky-DaganDepartment of Genetics, Hadassah Medical Organization, Jerusalem, Israel.
Amit GranitDepartment of Genetics, Hadassah Medical Organization, Jerusalem, Israel.
Matthew McDougalAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Taeyoung HwangDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Israel AntmanDepartment of Genetics, Hadassah Medical Organization, Jerusalem, Israel.
Rotem KarniDepartment of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Wan Hee YoonAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Ann SaadaDepartment of Genetics, Hadassah Medical Organization, Jerusalem, Israel.
Adi InbalFaculty of Medicine, Hebrew University of Jerusalem, Israel.
Tamar HarelDepartment of Genetics, Hadassah Medical Organization, Jerusalem, Israel.

Funding

GEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6M
Systematic understanding of RNA-centric mechanisms of gene regulation in chromatinR35GM160013 · NIGMS · LIEBER INSTITUTE, INC. · PI Taeyoung Hwang · 2025 to 2026
$919k
NIA NIH HHS T32 AG052363NIGMS NIH HHS R35 GM160013
6 · The paper itself

Abstract

Pathogenic variants in

Indexed as

Allele-specific antisense oligonucleotides (ASOs)ATAD3Adominant-negativeRNA therapyzebrafish

Identifiers

PMID42239176
PMCPMC13228611

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.