Evidence map›Paper›PMID 42239174›Full record

ArticlebioRxiv : the preprint server for biology2026

Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanism.

Wei Tian, Siyu Chen, Liqi Yao, Vignesh Kasinath, Karolin Luger

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wei TianDepartment of Biochemistry, University of Colorado Boulder.ORCID 0009-0000-0711-2046
Siyu ChenHoward Hughes Medical Institute.ORCID 0000-0003-4565-4772
Liqi YaoDepartment of Biochemistry, University of Colorado Boulder.ORCID 0000-0001-8344-6531
Vignesh KasinathDepartment of Biochemistry, University of Colorado Boulder.ORCID 0000-0003-2686-0546
Karolin LugerDepartment of Biochemistry, University of Colorado Boulder.ORCID 0000-0001-5136-5331

Funding

Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5M
Structure and Mechanism of Epigenetic Gene SilencingR35GM155426 · NIGMS · UNIVERSITY OF COLORADO · PI Vignesh Kasinath · 2024 to 2026
$1.2M
Modernization/operational improvements to basic centrifugation infrastructure of the Shared Instruments Pool in the Department of Biochemistry University of Colorado BoulderR24OD033699 · OD · UNIVERSITY OF COLORADO · PI ERBSE, ANNETTE H · 2022 to 2022
$143k
NIGMS NIH HHS R24 GM154185NIGMS NIH HHS R35 GM155426NIH HHS R24 OD033699
6 · The paper itself

Abstract

The restoration of chromatin in the wake of a DNA or RNA polymerase is essential to maintain the integrity of eukaryotic genomes. Human HIRA is a 1.8-megadalton, three-subunit histone chaperone that mediates all replication-independent deposition of the histone variant H3.3 at active chromatin regions

Identifiers

PMID42239174
PMCPMC13228460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.