ArticlebioRxiv : the preprint server for biology2026
Transcript architecture predetermines m6A remodeling and sensory neuron vulnerability in chemotherapy-induced peripheral neuropathy.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
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Funding
Abstract
Whether individual transcripts carry intrinsic features that predetermine their response to perturbations is unknown. Here we used nanopore direct RNA sequencing of male mouse dorsal root ganglia (DRG) to simultaneously profile N6-methyladenosine (m6A) modifications, poly(A) tail dynamics, and full-length isoform identity from mice treated with bortezomib, a proteasome inhibitor that causes painful peripheral neuropathy. Machine learning revealed that transcript-intrinsic features predetermine the magnitude of perturbation-induced m6A loss (R
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