Evidence map›Paper›PMID 42239129›Full record

ArticlebioRxiv : the preprint server for biology2026

Loss of Flotillin-2 enhances trastuzumab emtansine internalization and cytotoxicity by relieving negative regulation of HER2 internalization in HER2-amplified cancers.

David J Wisniewski, Rachel K Pritz, Jake Munch, Diya Desai, Tzu-Ting Huang, Sachin Kumar Deshmukh, Sharon Wu, Laurent Désaubry, George W Sledge, Jung-Min Lee and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David J WisniewskiWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD.
Rachel K PritzWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD.
Jake MunchWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD.
Diya DesaiWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD.
Tzu-Ting HuangWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD.
Sachin Kumar DeshmukhCaris Life Sciences, Phoenix AZ.
Sharon WuCaris Life Sciences, Phoenix AZ.
Laurent DésaubryINSERM-University of Strasbourg, UMR 1260, Regenerative Nanomedicine, Center of Research in Biomedicine of Strasbourg, Strasbourg, France.
George W SledgeCaris Life Sciences, Phoenix AZ.
Jung-Min LeeWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD.
Natalie Porat-ShliomThoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Stanley LipkowitzWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD.ORCID 0000-0002-6103-2255

Funding

Cbl Proteins as Regulators of Tyrosine Kinase SignalingZIABC010977 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LIPKOWITZ, STANLEY · 2009 to 2025
$13.4M
Intramural NIH HHS ZIA BC010977
6 · The paper itself

Abstract

While Trastuzumab emtansine (T-DM1) and other HER2-targeting antibody-drug conjugates (ADCs) are used to treat cancer patients with HER2-amplified tumors, there is a need to improve the efficacy through the understanding of their mechanism of uptake into cells. Flotillin-2 (FLOT2) regulates the internalization of epidermal growth factor receptor (EGFR), leading us to investigate FLOT2 effects on HER2 internalization. Higher FLOT2 expression in nine HER2 amplified cell lines correlated with a higher T-DM1 IC50

Identifiers

PMID42239129
PMCPMC13228603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.