Evidence map›Paper›PMID 42239120›Full record

ArticlebioRxiv : the preprint server for biology2026

Vision shapes neural maps of space through an ancient midbrain pathway.

Joshua M Brenner, Sarah Ruediger, Cameron Wilhite, Josue M Regalado, Yuta Senzai, Yuliya Voskobiynyk, Jeanne T Paz, Massimo Scanziani, Riccardo Beltramo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joshua M BrennerDepartment of Physiology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0001-8656-3872
Sarah RuedigerDepartment of Physiology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0001-6684-4693
Cameron WilhiteDepartment of Physiology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0002-5655-2010
Josue M RegaladoDepartment of Physiology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0002-6798-3860
Yuta SenzaiDepartment of Physiology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0002-2990-9889
Yuliya VoskobiynykGladstone Institute of Neurological Disease, Department of Neurology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0003-4169-3002
Jeanne T PazGladstone Institute of Neurological Disease, Department of Neurology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0001-6339-8130
Massimo ScanzianiDepartment of Physiology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0002-5331-9686
Riccardo BeltramoDepartment of Physiology, University of California, San Francisco; San Francisco, CA, USA.ORCID 0000-0002-3125-2089

Funding

Neural Circuits for the Cortical Control of the Optokinetic ReflexR01EY025668 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCANZIANI, MASSIMO · 2016 to 2020
$2.0M
Role of the Superior Colliculus in Orienting Eye Movements during REM SleepR00EY033850 · NEI · NORTHWESTERN UNIVERSITY · PI Yuta Senzai · 2025 to 2026
$498k
Role of the Superior Colliculus in Orienting Eye Movements during REM SleepK99EY033850 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SENZAI, YUTA · 2023 to 2024
$224k
An Expanded Visual Cortex for the Superior ColliculusF31EY033661 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRENNER, JOSHUA · 2022 to 2023
$67k
NEI NIH HHS F31 EY033661NEI NIH HHS K99 EY033850NEI NIH HHS R00 EY033850NEI NIH HHS R01 EY025668Wellcome Trust
6 · The paper itself

Abstract

Mammals rely on their senses to establish their position in space. Neural activity in the hippocampus maps position, yet how sensory signals reach the hippocampus remains poorly understood. Here we uncover the visual pathways informing spatial maps in the mouse hippocampus. Hippocampal activity in mice traversing a track in alternating periods of light and darkness revealed two distinct maps, one in light and one in dark. Surprisingly, distinct maps persisted following bilateral ablations of primary visual cortex, indicating that visual signals still reach the hippocampus. Conversely, blocking the ancestral pathway linking superior colliculus to lateral visual cortex markedly reduced the difference between light and dark maps. Thus, this conserved pathway relays visual information to the hippocampus, potentially explaining residual visual navigation in cortically blind humans.

Identifiers

PMID42239120
PMCPMC13228374

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.