Evidence map›Paper›PMID 42239117›Full record

ArticlebioRxiv : the preprint server for biology2026

The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes.

Mary E W Collier, Georgia Ceeney, Joshua Chiappelli, Sathyasaikumar Korrapati, Thong Huy Cao, Paulene Quinn, Junfeng Ma, Aashti Shauriq, Nicolas Sylvius, Edward J Hollox and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mary E W CollierDivision of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.ORCID 0000-0002-2088-4013
Georgia CeeneySchool of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB.
Joshua ChiappelliDepartment of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sathyasaikumar KorrapatiDepartment of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Thong Huy CaoDivision of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.
Paulene QuinnDivision of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.
Junfeng MaManchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK.
Aashti ShauriqDivision of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.
Nicolas SylviusGenomics Core Facility, University of Leicester, Leicester, UK.
Edward J HolloxDivision of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.
Donald J L JonesLeicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.
Andrew HudsonSchool of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB.
Elliot L HongDepartment of Psychiatry and Behavioural Sciences, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Nigel ScruttonManchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK.
Robert SchwarczDepartment of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Flaviano GiorginiDivision of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.

Funding

The Effects of Kynurenine Aminotransferase Inhibition in People with SchizophreniaP50MH103222 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHWARCZ, ROBERT · 2014 to 2023
$25.2M
NIMH NIH HHS P50 MH103222
6 · The paper itself

Abstract

Background: The single nucleotide polymorphism (SNP) rs1053230 within the kynurenine 3-monooxygenase ( Methods: Here we performed the first Results: HEK293T cells expressing KMO-Arg452 or KMO-Cys452 with a red fluorescent protein (RFP) tag produced equivalent levels of KMO mRNA, protein and enzymatic activity, and localised to mitochondria to the same extent. However, cycloheximide-mediated inhibition of protein translation revealed a striking reduction in protein stability of KMO-Arg452-RFP. KMO-RFP-trap pull-down followed by tandem liquid-chromatography-mass spectrometry (LC-MS/MS) identified dramatic differences in protein partners between KMO variants. Indeed, gene ontology-term enrichment analysis revealed that terms associated with synaptic function were more highly enriched amongst KMO-Cys452 interacting proteins. rs1053230 genotype was found to associate with chronic, trait-like depressive mood symptoms in patients. rs2275163 genotype had no effect on Conclusions: Differences in protein stability and protein-protein interactions may underlie the mechanisms by which the KMO rs1053230 genotype influences neuronal function, leading to cognitive differences in psychiatric conditions.

Indexed as

kynurenine 3-monooxygenaseKynurenine pathwayrs1053230rs2275163schizophreniasingle nucleotide polymorphism

Identifiers

PMID42239117
PMCPMC13228610

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