Evidence map›Paper›PMID 42239092›Full record

ArticlebioRxiv : the preprint server for biology2026

Neuroprotection following FLASH-RT may be mediated by sustained glutamate receptor AMPAR activation in CA3 neurons.

Louis V Kunz, Aymeric Almeida, Michèle Knol, Benoît Petit, Eniko A Kramár, Marcelo A Wood, Charles L Limoli, Marie-Catherine Vozenin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Louis V KunzRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland.ORCID 0009-0008-6526-6025
Aymeric AlmeidaRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland.ORCID 0009-0006-0136-6815
Michèle KnolRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland.
Benoît PetitRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland.ORCID 0000-0002-9886-8603
Eniko A KramárDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.ORCID 0009-0003-2279-7743
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.ORCID 0000-0003-2029-4176
Charles L LimoliDepartment of Radiation Oncology, University of California, Irvine, CA 92617 USA.ORCID 0000-0002-1321-4142
Marie-Catherine VozeninRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland.ORCID 0000-0002-2109-8073

Funding

Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
Improving pediatric brain tumor treatments using FLASH radiotherapyR01CA254892 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Charles Limoli · 2021 to 2026
$2.5M
NCI NIH HHS P01 CA244091NCI NIH HHS R01 CA254892
6 · The paper itself

Abstract

To elucidate the early mechanisms underlying the long-term neuroprotective effect of FLASH-RT in the normal brain, spatial transcriptomics (Nanostring) were performed after whole-brain irradiation of C57BL/6J mice with either 1 or 3 fractions of 10 Gy at 5.6×10

Identifiers

PMID42239092
PMCPMC13228234

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.