Evidence map›Paper›PMID 42239088›Full record

ArticlebioRxiv : the preprint server for biology2026

Live cell imaging reveals paclitaxel-induced lysosome motility and function disruption in DRG neurons.

Kathleen Cate Domalogdog, Ishwarya Sankaranarayan, Úrzula Franco-Enzástiga, Juliet M Mwirigi, Shani Mai Nguyen, Diana Tavares-Ferreira, Theodore J Price

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathleen Cate DomalogdogDepartment of Neuroscience, The University of Texas at Dallas, Richardson, TX 75080, USA.
Ishwarya SankaranarayanDepartment of Neuroscience, The University of Texas at Dallas, Richardson, TX 75080, USA.
Úrzula Franco-EnzástigaDepartment of Neuroscience, The University of Texas at Dallas, Richardson, TX 75080, USA.
Juliet M MwirigiDepartment of Neuroscience, The University of Texas at Dallas, Richardson, TX 75080, USA.
Shani Mai NguyenDepartment of Neuroscience, The University of Texas at Dallas, Richardson, TX 75080, USA.
Diana Tavares-FerreiraDepartment of Neuroscience, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0003-0986-3630
Theodore J PriceDepartment of Neuroscience, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0002-6971-6221

Funding

Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Diana Tavares Ferreira · 2022 to 2026
$13.6M
Translation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7M
NINDS NIH HHS R01 NS065926NINDS NIH HHS U19 NS130608
6 · The paper itself

Abstract

Lysosomal trafficking and homeostasis are biological functions that are pivotal for DRG neurons, given their metabolic demands and extremely long axons. Previous studies indicate that lysosomal signaling is altered in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN) and that blocking mitogen activated protein kinase-associated kinase (MNK1/2) signaling can alleviate pain behaviors in CIPN. Here, we investigated lysosome dynamics and lysosome-associated signaling in a mouse model of CIPN induced by paclitaxel (PTX), a chemotherapeutic agent used for various types of cancer. Using spinning disk super-resolution microscope (SPINSR), we demonstrate that PTX treatment

Indexed as

CIPNlive cell imaginglysosomepaclitaxelperipheral neuropathy

Identifiers

PMID42239088
PMCPMC13228573

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.