Evidence map›Paper›PMID 42239050›Full record

ArticlebioRxiv : the preprint server for biology2026

Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model of

Sashmita Panda, Diana Jazmin Ixmatlahua Ribera, Luis A Williams, Sheng Tang, Karthiayani Harikrishnan, Vaibhav Joshi, Steven J Ryan, Chinwendu Obi Obasi, Linda Laux, Enrique Rojas and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sashmita PandaDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.ORCID 0000-0003-4479-9662
Diana Jazmin Ixmatlahua RiberaDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.ORCID 0009-0004-5896-0722
Luis A WilliamsQuiver Bioscience, Cambridge MA, USA.
Sheng TangDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.
Karthiayani HarikrishnanQuiver Bioscience, Cambridge MA, USA.
Vaibhav JoshiQuiver Bioscience, Cambridge MA, USA.
Steven J RyanQuiver Bioscience, Cambridge MA, USA.ORCID 0000-0003-3650-7746
Chinwendu Obi ObasiDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.
Linda LauxDepartment of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL.
Enrique RojasDepartment of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL.
Owen McManusQuiver Bioscience, Cambridge MA, USA.
Graham T DempseyQuiver Bioscience, Cambridge MA, USA.ORCID 0000-0002-9273-7506
Alfred L GeorgeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.ORCID 0000-0002-3993-966X
Scott K AdneyDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.ORCID 0000-0001-8743-5944

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1M
Multi-scale disease modeling of SCN2A-related epilepsy due to gain-of-function variantsK08NS121601 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCOTT K. ADNEY · 2022 to 2026
$1.1M
NINDS NIH HHS K08 NS121601NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42239050
PMCPMC13228328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.