Evidence map›Paper›PMID 42239047›Full record

ArticlebioRxiv : the preprint server for biology2026

Spatiotemporal Transcriptomic Dissection Uncovers Age-Dependent Deceleration of Esophageal Cell Differentiation.

Jinho Jang, Jie Zhang, Amy S Park, Sohee Jun, Jae-Il Park, Kyung-Pil Ko

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinho JangDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0009-0002-2668-241X
Jie ZhangDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Amy S ParkDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sohee JunDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jae-Il ParkDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-0737-2654
Kyung-Pil KoDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-9554-5972

Funding

CRACD-controlled cell plasticity and small cell lung cancerR01CA278967 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jae-Il Park, Kwon-Sik Park · 2024 to 2026
$1.8M
Esophageal Squamous Cell Cancer Initiation and Immune Landscape RemodelingR01CA278971 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jae-Il Park · 2024 to 2026
$1.7M
Esophageal squamous cell cancer initiation and immune landscape remodelingK99CA286761 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KO, KYUNG PIL · 2024 to 2025
$258k
Esophageal squamous cell cancer initiation and immune landscape remodelingR00CA286761 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Kyung Pil Ko · 2026 to 2026
$249k
Targeting of E-cadherin-negative diffuse-type gastric cancerR03CA296049 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PARK, JAE-IL · 2025 to 2025
$164k
Modeling Esophageal Squamous Cell Cancer InitiationR03CA256207 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PARK, JAE-IL · 2021 to 2022
$162k
NCI NIH HHS K99 CA286761NCI NIH HHS R00 CA286761NCI NIH HHS R01 CA278967NCI NIH HHS R01 CA278971NCI NIH HHS R03 CA256207NCI NIH HHS R03 CA296049
6 · The paper itself

Abstract

Precise orchestration of stem and progenitor cells is essential for tissue homeostasis and regeneration but becomes dysregulated during aging. Despite the known markers, the age-related dynamics of esophageal epithelial cell lineages remain unclear. Using single-cell single cell transcriptomics, we analyzed human esophageal epithelia across different age groups. We identified two stem cell populations: quiescent (qeSCs) and proliferative (peSCs) esophageal stem cells. qeSCs from young donors showed higher

Indexed as

agingesophagussingle-cell RNA-sequencingspatial transcriptomicsstem cells

Identifiers

PMID42239047
PMCPMC13228450

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.