Evidence map›Paper›PMID 42239039›Full record

ArticlebioRxiv : the preprint server for biology2026

Flow-driven delivery boosts antibiotic effectiveness by overwhelming bacterial defenses.

Alexander M Shuppara, Matthias D Koch, Joseph E Sanfilippo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander M ShupparaDepartment of Biochemistry, University of Illinois at Urbana-Champaign; Urbana, IL, 61801, USA.ORCID 0000-0002-0838-637X
Matthias D KochDepartment of Biology, Texas A&M University; College Station, TX, 77843, USA.ORCID 0000-0003-4408-9900
Joseph E SanfilippoDepartment of Biochemistry, University of Illinois at Urbana-Champaign; Urbana, IL, 61801, USA.

Funding

Bacterial stress responses and surface adhesion in shear flowR35GM155443 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Joseph Sanfilippo · 2024 to 2026
$1.1M
Understanding type IV pili on the singe-molecule levelR35GM155280 · NIGMS · TEXAS A&M UNIVERSITY · PI Matthias Daniel Koch · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM155280NIGMS NIH HHS R35 GM155443
6 · The paper itself

Abstract

Physical, chemical, and biological factors collectively determine antibiotic effectiveness. However, laboratory studies often consider only one or two of these factors and fail to capture key interaction effects. Here, we use microfluidics to study the interplay of host-relevant shear flow, the antibiotic gentamicin, and the human pathogen

Identifiers

PMID42239039
PMCPMC13228580

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.