ReviewJADA foundational science2023
Molecular systems architecture of host-microbiome interactions in periodontitis.
Review in JADA foundational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Molecular Systems Architecture of Fibrotic Lung Microenvironment in Idiopathic Pulmonary Fibrosis.Cells · 2026Pooled it
- A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis.NPJ systems biology and applications · 2025Pooled it
- A molecular systems architecture of the mesenchymal stromal cell microenvironment.Stem cells (Dayton, Ohio) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To develop a systems-level understanding of host-microbial interactions that lead to the pathogenesis of periodontitis. Such an understanding may identify therapeutic targets for developing efficacious treatments for periodontitis. Search Strategy: Three databases are searched for relevant peer-reviewed articles published from January 1980 through April 2022. Citation Sources: The citation sources include PubMed, MEDLINE, and Google Scholar. Study Selection Criteria: The systems biology tool CytoSolve (CytoSolve) was used to perform the systematic review and to support the curation and development of the molecular systems architecture of periodontitis pathogenesis. Full-length articles that contained Medical Subject Headings key words relevant to periodontitis pathogenesis were selected for a comprehensive review. Data Elements Included: The molecular interactions across the 8 cell types-gingival epithelial, fibroblast, periodontal ligament, endothelial, keratinocyte, microbial, bone, and immune-of the periodontal microenvironment that leads to the pathogenesis of periodontitis are identified. These interactions are organized into 14 molecular systems involved in periodontitis. Overall Conclusions: A molecular systems architecture is developed to provide a visual framework for comprehending the complexity of molecular interactions across the 8 cell types involved in periodontitis pathogenesis. The resulting architecture may be used for target identification and discovery of single and multicombination therapeutics to treat periodontitis more effectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.