ArticleFrontiers in microbiology2026
A defined microbiota mouse model for
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: In this study, we utilized gnotobiotic mice harboring the altered Schaedler flora (ASF) from either C3H/HeN or 129S6/SvEv genetic backgrounds. These mice, subjected to various inflammatory conditions, were orally challenged with SPtA. The colonization and persistence of the pathogen were assessed in both intestinal and extraintestinal tissues, while also examining changes in gut microbiota, the expression of tight junction proteins, cytokines, and histopathological changes. Results: Our findings revealed that both the inflammatory state and the sex of the ASF mice significantly affected the colonization of SPtA. Notably, infection of the 129S6/SvEv Conclusion: The results of this study suggest that ASF mice represent a suitable low-cost model for investigating the pathogenesis of SPtA infection. The presence of ASF creates an open niche for SPtA colonization, allowing for the retention of a defined microbiome. This enables researchers to study perturbations in the microbiome without the limitations inherent to an antibiotic-treated model alternative. Furthermore, the chronic inflammatory conditions associated with
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