Evidence map›Paper›PMID 42238877›Full record

ArticleFrontiers in microbiology2026

Enhanced virulence and neuroinvasion of contemporary

Ellen Caroline Nobre Santos, Nathália Costa Silva, Luiza Godoy Rodrigues Pinto, Luiz Gustavo Pontes Santos, Juliana da Silva Brandi Oliveira, Melissa Teixeira Goulart, Marcele Neves Rocha, Isaque João da Silva de Faria, Renan Pedra de Souza, Silvana F de Mendonça and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ellen Caroline Nobre Santos *Mosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Nathália Costa Silva *Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luiza Godoy Rodrigues PintoDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luiz Gustavo Pontes SantosDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Juliana da Silva Brandi OliveiraDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Melissa Teixeira GoulartDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Marcele Neves RochaDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Isaque João da Silva de FariaDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Renan Pedra de SouzaMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Silvana F de MendonçaMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Livia BaldonMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Yaovi M H TodjiroMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Amanda C de FreitasMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Rafaela L MoreiraMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Maria E C RodriguesMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Siad AmadouMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
José M G FernandesMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Natália R GuimarãesMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Talita E R AdelinoMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Sara C F Dos SantosMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Felipe C M IaniFundação Ezequiel Dias, Belo Horizonte, Brazil.
Keldenn M F MorenoMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
João P P de AlmeidaDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luiz AlcantaraMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Marta GiovanettiMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.
Fabíola Mara RibeiroDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Álvaro G A FerreiraMosquitos Vetores, Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oropouche virus (OROV) is an orthobunyavirus undergoing dramatic re-emergence and rapid geographic expansion across Central and South America, coinciding with the emergence of reassortant lineages carrying novel segment combinations and adaptive mutations. Despite extensive genomic and epidemiological characterization, the biological mechanisms driving OROV resurgence during 2023-2024 remain unclear. Here, we show that contemporary reassortant OROV isolates exhibit markedly enhanced virulence in the AG129 mouse model compared with the historical prototype strain OROV

Indexed as

AG129 strain micearthropod-borne virosescentral nervous systemneuroinvasionOropouche virustissue tropismviremia

Identifiers

PMID42238877
PMCPMC13226609

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.