ArticleNeurosciences (Riyadh, Saudi Arabia)2026
Morphological and Molecular Characterization of Infant-Type Hemispheric Glioma.
Article in Neurosciences (Riyadh, Saudi Arabia), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To characterize the clinical, histopathological, and molecular features of infant-type hemispheric glioma (IHG) and explore any overlaps it might have with other types of pediatric gliomas. Methods: Data from the Children's Brain Tumor Network (CBTN) were analyzed (last accessed in January 2025), with a focus on patients aged 0-4 years with gliomas, glioneuronal tumors, or ependymomas. This analysis encompassed the clinical, histological, and molecular profiles of the cases, including those with recurrent tumors. The study scrutinized the tumor circumscription, grading features, and molecular alterations, along with the Methylation Class, using methylation profiling via the Heidelberg v12.5 and v12.8 classifiers. Results: IHG is predominantly well-circumscribed, but recurrence may lead to infiltrative growth. Novel findings include the acquisition of additional genetic alterations in recurrent IHG, which alters prognosis. One case exhibited progression to a pleomorphic xanthoastrocytoma-like profile, while another acquired glioblastoma-like infiltrative pattern and Conclusion: This study emphasizes the heterogeneity of IHG and underscores the necessity for molecular surveillance in recurrent instances. The findings aid in refining diagnostic criteria and understanding the prognostic implications of genetic alterations in IHG.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.