ArticleBreast cancer : basic and clinical research2026
Low Frequency of Pathogenic Variants in BRCA1 Exons 11/20 and BRCA2 Exon 11 Suggests Divergent Mutational Hotspots in Sudanese Breast Cancer Patients: A Case-Control Study.
Article in Breast cancer : basic and clinical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Breast cancers represent a heterogeneous group of diseases; approximately 7% may be attributed to inherited pathogenic variants in Objectives: This study aimed to investigate the frequency and nature of sequence variants in Design: This was a case-control study conducted at Shendi's Tumor Treatment and Cancer Research Center in Northern Sudan. Methods: The study included fifty-two female breast cancer patients and thirty healthy female controls aged at least 18 years. Demographic data and blood samples were collected for genomic DNA extraction. Polymerase Chain Reaction (PCR) and Sanger sequencing were performed for Results: Invasive ductal carcinoma was the predominant histological type, significantly associated with grade II tumors (P = 0.0001). Non-hereditary breast cancers were more prevalent (55.8%), with second-degree relatives most commonly affected in hereditary cases (69.6%). Three Conclusion: No pathogenic variants were identified in
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