Evidence map›Paper›PMID 42238784›Full record

ArticleCurrent opinion in endocrine and metabolic research2023

Nutrient uptake and metabolism in osteoblasts.

Courtney M Karner, Fanxin Long

Abstract read
In one paragraph

Article in Current opinion in endocrine and metabolic research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Courtney M KarnerDepartment of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas TX, 75390.
Fanxin LongTranslational Research Program in Pediatric Orthopaedics, The Children's Hospital of Philadelphia, Department of Orthopaedic Surgery, University of Pennsylvania.

Funding

Role of Glutamine Metabolism During Osteoblast Differentiation and Bone FormationR01AR071967 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI Courtney Michael Karner · 2018 to 2026
$3.5M
The cell metabolism basis for bone complications in type I diabetesR01DK125498 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LONG, FANXIN · 2021 to 2024
$1.8M
The Role of Proline Metabolism During Osteoblast Differentiation and Bone FormationR01AR076325 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI KARNER, COURTNEY MICHAEL · 2020 to 2024
$1.6M
NIAMS NIH HHS R01 AR071967NIAMS NIH HHS R01 AR076325NIDDK NIH HHS R01 DK125498
6 · The paper itself

Abstract

Osteoblasts are the chief bone-making cells that specialize in producing and mineralizing large amounts of type I collagen and other matrix proteins. The bioenergetics in support of the energy-intensive osteoblast activity is not well understood but has gained renewed interest in recent years. Research in the past ten years has not only confirmed glucose as the main energy substrate for osteoblasts, but also identified contributions of amino acids and fatty acids to either bioenergetic or biosynthetic processes in the cell. Moreover, osteogenic signals have been functionally linked to substrate utilization in osteoblasts. The brief review aims to summarize the recent findings, and to identify remaining questions in the emerging field.

Identifiers

PMID42238784
PMCPMC13229547

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.