ArticleFood chemistry: X2026
Critical regulatory pathways for the development of sheep myoblasts and the enhancement of cultured meat quality.
Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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7 authors.
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Abstract
Efficient myogenic cell development is vital for scaling cultured meat production, with metabolic pathways driving myoblast proliferation and differentiation. This study integrated metabolomics and lipidomics to monitor metabolic shifts during sheep myoblasts (SMs) development over six days, encompassing proliferation, early differentiation, and late differentiation phases. These stages involved SMs expansion, myoblast-to-myocyte differentiation, and myocyte fusion into myotubes, respectively, confirmed by upregulated myogenic markers (MyoD, Myomaker, MyHC) and extracellular matrix components (Desmin). Purine metabolism regulated overall SMs development, while glutathione metabolism supported proliferation and early differentiation, and lipid metabolism was critical during differentiation. The folate-mediated one‑carbon pool supported proliferation, coordinated nucleotide, lipid, and redox remodeling drove early differentiation, and membrane lipid remodeling supported late myotube formation. Furthermore, these interconnected metabolic pathways promote nutrient enrichment and the accumulation of flavor precursors. These stage-specific metabolic insights provide a foundation for optimizing cultured meat production, improving efficiency and quality.
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