ArticleJournal of inflammation research2026
MAIT Cells Maintain Intestinal Homeostasis Through IL-22 in an Experimental Colitis.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Mucosa-associated invariant T (MAIT) cells are a unique subset of innate-like lymphocytes abundant in the gastrointestinal tract, yet their role in maintaining intestinal homeostasis remains incompletely understood. We investigated how MAIT cells contribute to epithelial barrier integrity and the molecular mechanisms underlying this process during experimental colitis. Methods: Acute colitis was induced by dextran sulfate sodium (DSS) in wild-type (WT) and MR1-deficient (MR1 Results: MAIT cells accumulated in the inflamed colon and displayed a tissue-specific activated phenotype during DSS-induced colitis. MR1 Conclusion: Our study identifies a novel MAIT-CCL2-AHR-IL-22 regulatory axis that that contributes to epithelial barrier protection during acute experimental colitis. MAIT cells appear to act not only as effector cells but also as upstream coordinators of IL-22-dependent mucosal repair, providing a mechanistic basis for targeting this pathway in intestinal inflammatory disease.
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