ArticleFrontiers in allergy2026
Analysis of factors influencing skin sensitivity test results of antivenom and its potential correlation with allergic reactions: a retrospective cohort study.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Snakebite remains a persistent public health concern, whether skin sensitivity testing for antivenom should be performed remains a subject of debate. Moreover, no study to date has been conducted to investigate the risk factors associated with antivenom skin sensitivity testing. Objective: This study aimed to analyze the factors influencing a positive skin test for antivenom following snakebite and to investigate the correlation between the antivenom skin test results, assessing the correlation between antivenom skin sensitivity testing and allergic reactions, as well as the necessity of performing such testing prior to antivenom administration. Methods: A retrospective analysis was conducted on snakebite cases presenting to our hospital between June 2013 and May 2020. Univariate and multivariate logistic regression analyses were employed to identify potential factors influencing a positive skin test reaction to antivenom in snakebite cases. Results: Among 2,495 patients with snakebite, the incidence of a positive skin test reaction to antivenom was 9.80%. The incidence of a positive skin test was significantly higher in female patients compared to male patients (11.56% vs. 8.32%, Conclusions: The findings of this study indicate that respiratory rate, thrombin time, and serum phosphorus level are independent risk factors for a positive result on the antivenom skin sensitivity test. A positive antivenom skin test result may be associated with the occurrence of allergic reactions. A comprehensive evaluation incorporating a positive skin test result to guide antivenom desensitization and prophylactic anti-allergy treatment may help reduce the incidence of allergic reactions and serum sickness. Therefore, the antivenom skin sensitivity test may serve as one of the sequential measures in the management and treatment of snakebite cases.
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