ArticleOsteoarthritis imaging2025
Microstructural imaging of the cartilaginous endplate in the intervertebral disc.
Article in Osteoarthritis imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1 Objective: Intervertebral disc (IVD) degeneration is a major risk factor for the development of chronic low back pain (LBP), affecting millions globally, particularly as they age. IVD degeneration can promote inflammation, and reduce spinal stability leading to compression of nerve roots. Research has primarily focused on the annulus fibrosus (AF) or nucleus pulposus (NP), with an unmet need to explore the physiology of the cartilaginous endplate (CEP) and its microstructural assessment in IVD degeneration. Imaging the microstructure of the CEP, a relatively thin layer between the IVD and vertebral body, is challenging. This mini-review discusses advanced imaging methods to capture the microstructure of the CEP. 2 Design: This narrative mini-review explores current methods for 3 Results: Advanced imaging techniques can provide detailed visualization of IVD microarchitecture, structural integrity, and degeneration, including CEP structure. Optical light microscopy techniques provide detailed 2D images of the CEP from stained or unstained IVD sections. Imaging the IVD in a 3D modality, such as contrast-enhanced µCT, enables a better understanding of the CEP's microstructural changes in IVD degeneration. 4 Conclusions: High-resolution 3D imaging of the CEP could be useful for visualizing and quantifying the response of degenerated tissue to experimental therapeutics
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Registered trials
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